Artann Laboratories

Bone UltraSonic Scanner

Breast Models

Tissue Elastometer

TRA Electronic Systems

Bone Ultrasonometry

Colonoscopy Force Monitor

Elasticity Imaging

Temperature Profile Spectroscopy

Droplet MicroChromatography

Muscle Hydration Monitor

Skin Elasticity Analyzer

TRA-Based Ultrasound Focusing

Muscle Hydration Monitor

Infant hydration monitor
proof-of-concept prototype

Body hydration level is critical in maintaining both physical and cognitive health. Body water weight loss—dehydration—impairs abilities and can lead to severe health problems, even death. Seemingly minimal dehydration can quickly lead to increased difficulty of physical work and the inability to focus on the task at hand. The Muscle Hydration Monitor (MHM) was developed based on our previous studies on correlation of tissue molecular composition and acoustic properties [1-4] and was supported, in part, by the Phase I SBIR funding from the Department of Defense for assessment of body hydration status in soldiers during deployment and training. The method implemented in MHM is based on the experimental fact that ultrasound velocity through the soft tissue is a linear function of the tissue water content. A prototype of MHM was extensively tested in animal tissues in vitro [5], and in human studies involving adult patients with lower limb edemas [6,7].

Applications of the MHM technology include rehabilitation and sports medicine, various research and clinical markets [8]. MHM could be used to monitor elderly and patients with a wide variety of clinical conditions resulting in changes in individual’s hydration level, including alterations in body fluids pre- and post-surgery, digestion problems, blood pressure, muscle cramps, and obesity. Another important application of MHM is in neonatology since dehydration is a leading cause of infant morbidity and mortality worldwide. In the United States, dehydration, secondary to gastroenteritis, accounts for 10% of hospital admissions. Today, physical examination remains the most useful bedside tool to detect dehydration and yet, its sensitivity remains suboptimal. Artann has developed an infant hydration monitor based on the MHM technology to objectively quantify soft tissue hydration at the infant’s bedside [9].

References

Sarvazyan AP, Lyrchikov AG: Correlation of bulk elastic properties of soft biological tissues with content of water, protein and fat. Biomechanics in Medicine and Surgery, Riga 1986; 1:353-8.
Sarvazyan AP, Lyrchikov AG, Gorelov SE: Dependence of ultrasonic velocity in rabbit liver on water content and structure of the tissue. Ultrasonics 1987; 25(4):244-7.
Sarvazyan AP: Elastic properties of soft tissue. Handbook of Elastic Properties of Solids, Liquids and Gases 2001; III(5), eds Levy, Bass, Stern, Academic Press:107-27.
Sarvazyan AP, Hill CR: Physical chemistry of the ultrasound-tissue interaction. Physical Principles of Medical Ultrasonics 2004; 7, eds Hill CR, Bamber JC, ter Haar GR, John Wiley & Sons:223-35.
Sarvazyan AP, Tatarinov A, Sarvazyan N: Ultrasonic assessment of tissue hydration status. Ultrasonics 2005; 43(8):661-71.
Topchyan A, Tatarinov A, Sarvazyan N, Sarvazyan AP: Ultrasound velocity in human muscle in vivo: Perspective for edema studies. Ultrasonics 2006; 44:259-64.
Sarvazyan A, Tatarinov A, Sarvazyan N: Ultrasonic assessment of tissue hydration status with perspective for edema evaluation. Abstracts of the International Congress on Ultrasonics 2007 Apr; Vienna, Austria:65.
Sarvazyan AP: Ultrasonic water content monitor and methods for monitoring tissue hydration. USA Pat 7,033,321 2006 Apr 25.
Sarvazyan AP: Infant hydration monitor. USA Pat 7,291,109 2007 Nov 6.



		Overview Research Team Partnerships Job Opportunities Bone UltraSonic Scanner Breast Models Tissue Elastometer TRA Electronic Systems Bone Ultrasonometry Colonoscopy Force Monitor Elasticity Imaging Temperature Profile Spectroscopy Droplet MicroChromatography Muscle Hydration Monitor Skin Elasticity Analyzer TRA-Based Ultrasound Focusing		Muscle Hydration Monitor Infant hydration monitor proof-of-concept prototype Body hydration level is critical in maintaining both physical and cognitive health. Body water weight loss—dehydration—impairs abilities and can lead to severe health problems, even death. Seemingly minimal dehydration can quickly lead to increased difficulty of physical work and the inability to focus on the task at hand. The Muscle Hydration Monitor (MHM) was developed based on our previous studies on correlation of tissue molecular composition and acoustic properties [1-4] and was supported, in part, by the Phase I SBIR funding from the Department of Defense for assessment of body hydration status in soldiers during deployment and training. The method implemented in MHM is based on the experimental fact that ultrasound velocity through the soft tissue is a linear function of the tissue water content. A prototype of MHM was extensively tested in animal tissues in vitro [5], and in human studies involving adult patients with lower limb edemas [6,7]. Applications of the MHM technology include rehabilitation and sports medicine, various research and clinical markets [8]. MHM could be used to monitor elderly and patients with a wide variety of clinical conditions resulting in changes in individual’s hydration level, including alterations in body fluids pre- and post-surgery, digestion problems, blood pressure, muscle cramps, and obesity. Another important application of MHM is in neonatology since dehydration is a leading cause of infant morbidity and mortality worldwide. In the United States, dehydration, secondary to gastroenteritis, accounts for 10% of hospital admissions. Today, physical examination remains the most useful bedside tool to detect dehydration and yet, its sensitivity remains suboptimal. Artann has developed an infant hydration monitor based on the MHM technology to objectively quantify soft tissue hydration at the infant’s bedside [9]. References Sarvazyan AP, Lyrchikov AG: Correlation of bulk elastic properties of soft biological tissues with content of water, protein and fat. Biomechanics in Medicine and Surgery, Riga 1986; 1:353-8. Sarvazyan AP, Lyrchikov AG, Gorelov SE: Dependence of ultrasonic velocity in rabbit liver on water content and structure of the tissue. Ultrasonics 1987; 25(4):244-7. Sarvazyan AP: Elastic properties of soft tissue. Handbook of Elastic Properties of Solids, Liquids and Gases 2001; III(5), eds Levy, Bass, Stern, Academic Press:107-27. Sarvazyan AP, Hill CR: Physical chemistry of the ultrasound-tissue interaction. Physical Principles of Medical Ultrasonics 2004; 7, eds Hill CR, Bamber JC, ter Haar GR, John Wiley & Sons:223-35. Sarvazyan AP, Tatarinov A, Sarvazyan N: Ultrasonic assessment of tissue hydration status. Ultrasonics 2005; 43(8):661-71. Topchyan A, Tatarinov A, Sarvazyan N, Sarvazyan AP: Ultrasound velocity in human muscle in vivo: Perspective for edema studies. Ultrasonics 2006; 44:259-64. Sarvazyan A, Tatarinov A, Sarvazyan N: Ultrasonic assessment of tissue hydration status with perspective for edema evaluation. Abstracts of the International Congress on Ultrasonics 2007 Apr; Vienna, Austria:65. Sarvazyan AP: Ultrasonic water content monitor and methods for monitoring tissue hydration. USA Pat 7,033,321 2006 Apr 25. Sarvazyan AP: Infant hydration monitor. USA Pat 7,291,109 2007 Nov 6.